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Brice Thompson ND, MS - Microbiome-Mediated Drug Interactions (1 Pharmacology CE Credit)

2021 Thaena Microbiome Symposium - Microbial Ecosystems, Metabolites(postbiotics), and Their Impact on Human Health (December 4-5, 2021)


The microbiome has been implicated as having an essential role in the efficacy and toxicity of several therapeutics, although these contributions are just beginning to be understood. Gut microbiota can have both direct and indirect metabolic effects on xenobiotics. In this presentation, we will describe how gut microbes have been found to modify the actions of nonsteroidal anti-inflammatory drugs, cardiac glycosides, and some chemotherapeutic agents. Further, we will discuss how non-antibiotic pharmaceuticals impact the microbiome and their implications for health and disease. Finally, we will cover how we might leverage the microbiome to improve therapeutic responses to both drugs and herbs.



  1. Define direct and indirect microbiome-mediated impacts on xenobiotic metabolism

  2. List known pharmaceutical-microbiome drug interactions

  3. Describe recent findings on microbiome changes in response to specific therapeutics

  4. Assess the therapeutic potential of the microbiome in determining treatment response to drugs and herbs



Brice is a Naturopathic Doctor and Researcher who loves drugs, herbs, immunology, and microbiology. He’s been involved in several research projects ranging from tuberculosis to obesity to microbiome metabolomics. He’s also been a contributing author in textbooks related to both natural medicine and pharmaceutics.

After graduating from the National University of Natural Medicine in 2018, he pursued additional research training at the University of Washington by completing a postdoctoral research fellowship in the Department of Pharmaceutics. He is currently finishing another graduate degree in pharmaceutics at UW, where his research has primarily focused on characterizing natural product-drug interactions. 



1 Pharmacology CE Credit - American Association of Naturopathic Physicians (AANP)

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